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Research Focus

The Statistical Genetics Laboratory studies the role that genetic variation plays in determining risk of disease and its risk factors.

The laboratory develops and applies statistical genetic methods to gene mapping studies across a wide range of traits and diseases.

One major focus is understanding genetic variation in various cancers, including melanoma, ovarian cancer and oesophageal cancer. This work will lead to a better understanding of why particular individuals are affected by cancer or why they respond poorly to cancer treatment.

Another major interest is ophthalmological genetics, with ongoing work to identify the specific genes involved in both eye disease and their underlying quantitative risk factors.

Gallery

Research Projects

Current Research Projects

Gene mapping studies on eye disease

Translation of gene discoveries in eye disease using approaches such as genetic prediction

The modifiable risk factors that actually cause cancer


Research Team

Xikun Han

Guiyan Ni

Marloes Helder

Mathias Seviiri


Funding

  • National Health and Medical Research Council
  • Council Cancer Queensland
  • Worldwide Cancer Research
  • Tour de Cure
  • Medical Research Future Fund
  • BrightFocus
  • Australian Skin and Skin Cancer Research Centre
  • QIMR Berghofer Christmas Appeal
  • Philanthropic support from The Great Priory of Queensland, Hand Hearts Pockets, Brian and Merle Dwyer, and the Laurence Edward Wilkins Foundation




Further Information



External Collaborations
  • Professor Jamie Craig, Flinders University
  • Dr Kathryn Burdon, University of Tasmania
  • Dr Alex Hewitt, University of Melbourne
  • Professor David Mackey, Lions Eye Institute
  • Professor Janey Wiggs, Harvard Medical School
  • Professor Georgia Long & Professor Richard Scolyer, Melanoma Institute Australia
  • Professor M. Tere Landi and Dr Kevin Brown, National Cancer Institute Bethesda, USA
  • Dr Mark Iles, University of Leeds
  • Professor Dan Chambers, Prince Charles Hospital
  • Professor Anne E Cust and Dr Julia Steinberg, The Daffodil Centre
  • Maciej Trzaskowski, IntelMagik Consultancy
  • Professor Dale Nyholt, Queensland University of Technology
  • Associate Professor Aideen McInerney-Leo and Professor
    Kiarash Khosrotehrani, University of Queensland
  • Professor Joseph Powell, Garvan Institute

In the media

Australian researchers find 45 new genetic causes of non-melanoma skin cancers

Australian researchers find 45 new genetic causes of non-melanoma skin cancers

Blindness and twins

Blindness and twins

Born with a taste for coffee or tea

Born with a taste for coffee or tea

Breakthrough in genome-wide study of eye disease

Breakthrough in genome-wide study of eye disease

Cancer research funded

Cancer research funded

Study finds being overweight is likely to cause cancer

Study finds being overweight is likely to cause cancer

Daily coffee doesn’t affect cancer risk

Daily coffee doesn’t affect cancer risk

Finding the genes behind oesophageal cancer

Finding the genes behind oesophageal cancer

Genes found for puberty

Genes found for puberty

Height is in your genes – but where?

Height is in your genes – but where?

Near-sightedness genes identified

Near-sightedness genes identified

New genetic insights into oesophageal cancer

New genetic insights into oesophageal cancer

New genetic markers could help predict onset of debilitating eye disease

New genetic markers could help predict onset of debilitating eye disease

Obesity boosts gullet cancer risk six-fold

Obesity boosts gullet cancer risk six-fold

Obesity-related gene linked to melanoma

Obesity-related gene linked to melanoma

Out of Africa

Out of Africa

Researchers close in on new melanoma gene

Researchers close in on new melanoma gene

Researchers identify 40 new genetic markers for Glaucoma

Researchers identify 40 new genetic markers for Glaucoma

Scientists develop test that will help prevent glaucoma-related blindness

Scientists develop test that will help prevent glaucoma-related blindness

Scientists double understanding of genetic risk of melanoma

Scientists double understanding of genetic risk of melanoma

Study finds vitamin D does not protect against most cancers

Study finds vitamin D does not protect against most cancers

Study identifies five new melanoma risk regions

Study identifies five new melanoma risk regions

Study offers insight into relationship between acid reflux and COVID-19

Study offers insight into relationship between acid reflux and COVID-19

Tiny gene. Big melanoma risk.

Tiny gene. Big melanoma risk.

Twins help unravel glaucoma genes

Twins help unravel glaucoma genes

Unravelling the melanoma mystery

Unravelling the melanoma mystery

World-first: Glaucoma genes found

World-first: Glaucoma genes found

Worldwide collaboration uncovers new genes linked to glaucoma risk

Worldwide collaboration uncovers new genes linked to glaucoma risk

New genetic research could help prevent ‘silent thief of sight’

New genetic research could help prevent ‘silent thief of sight’

It's known as the “silent thief of sight” - sneakily stealing the sight in one eye as the other covers for it. 300,000 Australians have glaucoma, around half don’t know it yet. Professor Stuart MacGregor explains the incredible genetic discoveries that could help prevent irreversible vision loss.
Genetic discovery could help prevent irreversible blindness in people with glaucoma

Genetic discovery could help prevent irreversible blindness in people with glaucoma