Research Focus
The controlled human malaria infection (CHMI) model has been used to evaluate >10 investigational medicinal products. Models have been established for an artemisinin-sensitive and an artemisinin-resistant P. falciparum strain and other Plasmodium species including P. vivax, P. malariae, and P. knowlesi. The model has also enabled the conduct of studies to evaluate transmission-blocking interventions and has enabled the conduct of exploratory studies to evaluate immunological and pathophysiological response to infection.
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Research Projects
Current Research Projects
Clinical trials to evaluate candidate anti-malarials.
Using the IBSM model to improve understanding of the pathogenesis of malaria.
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Research Team
Adam Potter
Arya SheelaNair
Azrin Rahman
Fiona Amante
Funding
- Clinical trials to evaluate candidate anti-malarials.
- The Bill and Melinda Gates Foundation.
Publications
Transmission blocking activity of low-dose Tafenoquine in healthy volunteers experimentally infected with Plasmodium falciparum.
Characterizing the Blood-Stage Antimalarial Activity of Tafenoquine in Healthy Volunteers Experimentally Infected With Plasmodium falciparum